Based on the research that has been done can be concluded that the bioactive compounds from sponges

Cervical cancer is cancer that many meperempuan. Currently cervical cancer ranks second of cancer that affects women in the world and the first order for women in developing countries, especially in Asia. In Indonesia alone, 34% of women stricken with cervical cancer. The low detection of cervical cancer is causing the increasing number of patients. One effort that cancer treatment trypsin is usually applied to patients is chemotherapy. However, this has the side effect of chemotherapy, because chemotherapy not only attack cancer cells but also other cells in the body are rapidly growing cells such as hair. So this way will lead to effects such as hair loss, performance degradation and even liver and kidney. As well as the kemunngkina effect because the virus resistant gene or mutation in its DNA. it is necessary for the existence of effective drugs and lower side effects.
One study that is being developed to produce cancer drugs is to use active compounds derived trypsin from a sponge or Geodia sp. That induces apoptosis in cancer cells. This study aims to determine the cytotoxicity of methanolic extract trypsin and chloroform extract Geodia sponge sp. Against HeLa cells (cervical trypsin cancer cell line). By chromatographic methods, showed that Geodia sp. Contain alkaloids, flavonoids, terpenoids and phenols. Compounds such as compounds that cause apoptosis (programmed cell death) in cancer cells. 93.5% of cervical trypsin cancer is caused by Human papilloma virus (HPV). Circular HPV genome, which has 8 ORF E1, E2, E4, E5, E6, E7 and L1 and L2. E6 and E7 proteins called oncogenes trypsin due to their ability to bind proapoptotic proteins, p53 and PRB so that infected cells actively proliferate into tumors to cytotoxic kanker.Pengujian Geodia sp. against Cancer cell line, showed the compound ethanolic, methanolic and chloroform cause p53 in HeLa cell line becomes inactive. this shows that extracts Geodia sp. As apoptosis inducers and more specific than Doksorobisin cancer drugs.
Based on the research that has been done can be concluded that the bioactive compounds from sponges Geodia sp. Potentially inhibit the growth of HeLa cells. A row starting with the most potential is the chloroform extract, ethanolic extract trypsin and methanolic ekstrakn. The effectiveness of the inhibition of the growth of HeLa cells extracts Geodia sp third, better than doxorubicin. Further research needs to be done on a sponge bioactive compounds Geodia sp. Regarding the isolation and fractionation of bioactive compounds Geodia trypsin sponge sp. Wediombo Beach. Comparison of the effectiveness of inhibition of growth of cancer cells by apoptin is a candidate anticancer future, as well as the necessary preclinical testing in animals to see the effects of the active compounds on normal cells.
GENOME