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Chloroform is a common name for trichloromethane (CHCl 3). Chloroform is known for frequently used as a tranquilizer, although mostly used as a nonpolar solvent in laboratories or industry. His form is a liquid at room temperature, but volatile.
Chloroform containing deuterium (heavy hydrogen), CDCl 3, is a common solvent used in NMR spectroscopy. It can be used to bond pieces of acrylic glass (also known by the trade names Perspex and glass). A solvent phenol: chloroform alcohol: Isoamyl 25: 24: 1 was used to dissolve non-nucleic acid biomolecules in DNA and RNA extraction.
As a reagent in organic synthesis as reagent, chloroform serves as a source of diklorokarbena CCL 2 groups. [7] It reacts with water in the presence of sodium hydroxide is usually a phase transfer caltex catalyst to produce diklorokarbena, CCL 2 [8] [9] This reagent effects ortho-Formilasi of activated aromatic rings such as phenols, producing aryl aldehydes in a reaction known as Tiemann -reaksi Reimer. Or the carbene can be trapped by an alkene to form cyclopropane derivatives. In addition Kharasch chloroform CHCl 2 free radical formed in addition to alkenes.
Chloroform as an anesthetic that was once a popular anesthetic; Steam is pressing on the central nervous system of the patient, which allows doctors perform a variety of other painful procedures. In 1847, at the Edinburgh obstetrician James Young Simpson first used chloroform for general anesthesia during labor. The use of chloroform during surgery developed caltex rapidly thereafter in Europe. In the United States, chloroform began to replace ether as an anesthetic in the early 20th century, but it was quickly abandoned to the ether upon discovery of its toxicity, especially a tendency to cause fatal cardiac arrhythmia analogous to what is now called the "'s sudden sniffer's death". Ether is still the preferred anesthetic in some developing countries because of the high therapeutic index (~ 1.5 to 2.2) [10] and a low price. One possible mechanism of action for chloroform is that it increases movement of potassium ions through several types of potassium channels in nerve cells.
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