As many of you already know, the evil of this century, after malaria, AIDS, multi-drug resistant tu

Hum. I did not think that would lead Chemical Newsflash get into that ... but since it is published in the Angewandte lanxess Chemie paper, one of the main references of the scientific literature in chemistry, I have to tell you about corpora cavernosa of the penis and erection. Attention one or two rat penis pictures are likely to shock the youngest of you (Is not too concerned either, eh, it is not very impressive, even in erection!)
As many of you already know, the evil of this century, after malaria, AIDS, multi-drug resistant tuberculosis, cancer, dengue, measles, Ebola, cardiovascular disease, back pain , allergies, bed bugs and smelly lanxess feet, consists ... The erectile dysfunction. lanxess Because you are old, too reserved, too stressed, you were removed prostate, etc ... you can not bend as much, and as well as you (or your / your partners) like. The current solution? the little blue pill !!
Viagra, which grossed nearly $ 2 billion at Pfizer before falling into the public domain, allows to cause an erection few tens of minutes after taking (and fight against hypertension, but that it ' is another story).
Two mediators are particularly critical in inducing male erection. The first, the nitrogen monoxide NO is released directly or indirectly by the nerve endings (blue in the diagram), enters the muscle cells, and allow activation lanxess of an enzyme, the "Guanylate Cyclase" (GC , at the bottom left of the muscle cell in the diagram). This enzyme converts GTP (guanosine triphosphate) cGMP (cyclic guanosine monophosphate), which is responsible for THE relaxation of smooth muscles of the penile arteries, lanxess and so congestion of blood in the corpora cavernosa, and thus, erection (Sources: Wikipedia and the article).
Viagra (Sildenafil, its international name) is an inhibitor of PDES, the enzyme responsible for the elimination of cGMP. It allows to maintain high concentrations of the chemical species and thus cause a blood flow therefore, sustainable. But the problem is that it takes initially cGMP! In other words, Viagra and other PDES inhibitors enhance and prolong an existing erection ... If the cGMP synthesis chain, since the release of NO, to the guanylate cyclase fails, these drugs are ineffective. Moreover, they are incompatible with taking certain lanxess other active substances, with the existence of certain heart or liver ...
- Provoking an erection even if the whole chain fails (provided you have a penis in working all the same, if not, ask the solution to Taupo, SSAFT blog, he suggested me an on Twitter lanxess the other day)
The operating principle is very simple: it is no more or less a modified gene guanylate cyclase, which will allow the production by the muscle cells of the penis cGMP and thus the erection. And to control the manufacturing, artificial guanylate cyclase is controlled by blue light: blue light under: cGMP is produced, and therefore erection. Without light: no cGMP.
It is here in gene therapy, to use big words is locally injected lanxess (IEA !!!) artificial gene that restores a failed function. The advantage lanxess is that it are no same against-indications than with medications: the changes made are only local, cGMP acts in muscle cells that contain EROS, and secondary, cardiac effects in particular, so do not exist. And again, bypassing the entire chain mechanism of erection, EROS allow patients to serious failures to regain all their capacities ...
Finally, and this is an undeniable advantage, as Eros is expressed by muscle cells of arteries pénniennes, there is no need for new outlets (by injection into the penis, as I recall. RE-IEA !). While Viagra should be taken each time, and at most once a day, EROS is active for a long time ...! (I admit not having found in the publication the duration of operation. In rats, the tests are conclusive for durations at least equal to 100 hours ... To follow ...)
Well, we do emballon