My ex-lab thesis is made of beautiful mastering chemistry chemistry. Well, it's synthetic methodology, so it's not very sexy, not very seller ... However, the team of Olivier Baudoin offer innovations in computer that really worth a visit.
Good text explanation ... When building molecules in organic chemistry, desired, most of the time, creating new bonds between carbon and other atoms or oxygen, or nitrogen. One of the most used methods is to provide a coupling between two molecules: mastering chemistry
and are the groups of atoms that we want to link together, when X and Y are the so-called "leaving groups", atoms or groups of atoms removed during the reaction. mastering chemistry Typically, X and / or Y are chlorine, bromine, iodine, or groups of relatively massive carbon. Finally, these coupling reactions are usually catalyzed by metals such as copper, palladium, rhodium, etc ...
The principle reactions with "CH activation" is to overcome the leaving groups: one will make coupling reactions that look more like this:
(I put quotation marks around the "HH" because the hydrogen will be mostly captured by additives to the reaction. In addition, it often remains one of the two groups X or Y ...).
Also catalyzed metals, primarily mastering chemistry palladium, these CH activations can prevent the introduction of leaving groups. But they are not easy: the bonds between the carbons and hydrogens are firstly difficult to break, on the other hand they are very numerous, and the usual reactions to change are not very specific, and will type some n anywhere in the molecule ... Yet many research teams are exploring this path may allow substantial simplifications in the synthesis of high-value complex products.
In this publication, D. Dailler and colleagues Lyon, achieved the synthesis of several marine natural products of the family aeruginosines, potential anti-viral. Which is pretty cool is that their work has in succession two CH activation reactions and allows the production mastering chemistry of end products in 17 steps, especially in quantities much greater mastering chemistry than previous syntheses: about 1 g 'aeruginosine 298A! (Yes, we are in fine chemistry, where 10 mg, it's nice, 100 mg, that is something a lot, and 1g, an almost industrial scale!)
"A mastering chemistry General and Scalable Synthesis of Marine mastering chemistry Natural Products Aeruginosin Based on Two Strategic C (sp 3) H Activation Reaction" D.Dailler, G. Danoun, O. Baudoin, Angew. Chem. Int. Ed. 2015, Early View
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